A universal strategy for preparing protected C-terminal peptides on the solid phase through an intramolecular click chemistry-based handle.
نویسندگان
چکیده
A new universal strategy exploits DKP formation in a dipeptide moiety whose C-terminal residue is blocked by a leaving group. It enables both synthesis of C-terminal protected peptides that are useful for convergent synthesis of large peptides and use of a C-terminal permanent protecting group that can be cleaved by catalytic hydrogenation to release the peptide.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 17 شماره
صفحات -
تاریخ انتشار 2012